The overall theme of the lab is understanding the molecular consequences of posttranslational modifications (PTMs) including glycosylation and ubiquitination. These modifications expand the chemical diversity available to cells and living organisms. We specifically focus on the development of chemical tools as attractive methods for dissecting these biochemical pathways.

Currently we are applying these chemical approaches to reveal roles for PTMs in cellular responses in processes associated with changes in metabolism and stress. Recent evidence suggests that these pathways are important contributors to a variety of human diseases including neurodegeneration and cancer. To accomplish our scientific goals, members of the lab use combinations of organic synthesis, genetics, protein biochemistry, and cellular biology. Interested prospective graduate students should apply to the chemistry PhD program, and postdoctoral candidates can email matthew.pratt@usc.edu directly.


Matthew R. Pratt, PhD Associate Professor

Departments of Chemistry and Biological Sciences and Member of the Norris Comprehensive Cancer Center
University of Southern California
3430 S. Vermont Ave, TRF 114B
Los Angeles, CA 90089
(213) 740-3014

Lab News

September 3rd, 2019 - Congratulations to Ana on winning the student poster award at the American Chemical Society national meeting in San Diego.

August 16th, 2019 - Congratulations to Paul, Aaron, and our host of excellent collaborators on publication of their paper in J Am Chem Soc

March - Congratulations to Narek on the publication of his Methods Enzymol chapter

January 16th - Congratulations to Paul, Aaron, Ana, Mariana, Cesar, and our great collaborators Anne-Laurie and Hilal Lashuel on our paper in Proc Natl Acad Sci

November 15th - Congratulations to Narek on his paper in ACS Chem Biol with Axel Schönthal at USC

September 26th - Congratulations to Anna for her contribution to a review in Chem Sci with Christophe Biot at the University of Lille

September 4th - Congratulations to Narek and our collaborators John and Linda Hsieh-Wilson at Caltech on our paper in Biochemistry

August 8th - Congratulations to Cesar and undergraduates Geoff and Marcos on their paper in Org Lett

July 7th - Congratulations to former members Lisa and Balyn, as well as Anna and Narek on acceptance of their paper in ChemBioChem